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ATP citrate synthase - Wikipedia
https://en.wikipedia.org/wiki/ATP_citrate_synthase
WebATP citrate synthase (also ATP citrate lyase (ACLY)) is an enzyme that in animals represents an important step in fatty acid biosynthesis. By converting citrate to acetyl-CoA, the enzyme links carbohydrate metabolism, which yields citrate as an intermediate, with fatty acid biosynthesis, which consumes acetyl-CoA.
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ATP-citrate lyase (ACLY) in lipid metabolism and ... - PubMed
https://pubmed.ncbi.nlm.nih.gov/31499095/
WebATP citrate lyase (ACLY) is an important enzyme linking carbohydrate to lipid metabolism by generating acetyl-CoA from citrate for fatty acid and cholesterol biosynthesis. Mendelian randomization of large human cohorts has validated ACLY as a promising target for low-density-lipoprotein-cholesterol ….
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ACLY Gene - GeneCards | ACLY Protein | ACLY Antibody
https://www.genecards.org/cgi-bin/carddisp.pl?gene=ACLY
WebJan 3, 2024 · ACLY (ATP Citrate Lyase) is a Protein Coding gene. Diseases associated with ACLY include Soft Palate Cancer and Colorectal Cancer. Among its related pathways are Innate Immune System and Integration of energy metabolism. Gene Ontology (GO) annotations related to this gene include obsolete cofactor binding and ATP citrate …
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Structure of ATP citrate lyase and the origin of citrate synthase in
https://www.nature.com/articles/s41586-019-1095-5
WebApr 3, 2019 · In autotrophic prokaryotes, ACLY is a hallmark enzyme of the reverse Krebs cycle (also known as the reductive tricarboxylic acid cycle), which fixates two molecules of carbon dioxide in...
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Molecular basis for acetyl-CoA production by ATP-citrate lyase
https://www.nature.com/articles/s41594-019-0351-6
WebDec 23, 2019 · An allosteric mechanism for potent inhibition of human ATP-citrate lyase. Article 03 April 2019. Main. ATP-citrate lyase (ACLY) is the predominant source of nucleocytosolic acetyl coenzyme A...
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Mendelian Randomization Study of ACLY and Cardiovascular Disease
https://www.nejm.org/doi/10.1056/NEJMoa1806747
WebFeb 22, 2024 · ATP citrate lyase is an enzyme in the cholesterol–biosynthesis pathway located upstream of 3-hydroxy-3-methylglutaryl–coenzyme A reductase (HMGCR). 1 Inhibition of ATP citrate lyase should...
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Exploring the Role of ATP-Citrate Lyase in the Immune System
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930476/
WebFeb 18, 2021 · One of the main enzymes catalyzing cytosolic acetyl-CoA formation is ATP-citrate lyase (ACLY). In addition to its classical function in the provision of acetyl-CoA for de novo lipogenesis, ACLY contributes to epigenetic regulation through histone acetylation, which is increasingly appreciated.
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ATP-citrate lyase controls endothelial gluco-lipogenic ... - Nature
https://www.nature.com/articles/s41419-023-05932-8
WebJul 6, 2023 · ATP-citrate lyase (ACLY) directs glucose metabolic fluxes to de novo lipogenesis by generating acetyl-Co-enzyme A (acetyl-CoA), which facilitates transcriptional priming via protein acetylation....
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ACLY Nuclear Translocation in Human Macrophages Drives Proinflammatory
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616537/
WebOct 30, 2021 · In this context, the metabolic enzyme ATP citrate lyase (ACLY), the producer of citrate-derived acetyl-coenzyme A (CoA), plays a critical role in supporting a proinflammatory response. Through immunocytochemistry and cytosol–nucleus fractionation, we found a short-term ACLY nuclear translocation.
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Identification and integrative analysis of ACLY and related gene …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8335999/
WebAug 3, 2021 · ATP citrate lyase (ACLY) is a cytosolic homotetrameric enzyme that catalyzes the conversion of citric acid to acetyl-CoA and oxaloacetate of citrate and coenzyme A (CoA) with the corresponding hydrolysis of ATP to ADP and phosphate [ 14 ].
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ATP citrate lyase (ACLY) inhibitors: An anti-cancer strategy at the
https://pubmed.ncbi.nlm.nih.gov/30195238/
WebSep 5, 2018 · ATP citrate lyase (ACLY) is a cytosolic homotetrameric enzyme that catalyzes the conversion of citrate and coenzyme A (CoA) to acetyl-CoA and oxaloacetate, with the simultaneous hydrolysis of ATP to ADP and phosphate. Interestingly, ACLY is a strategic enzyme linking both the glycolytic and lipidic metabolism.
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ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch
https://www.cell.com/cell-reports/fulltext/S2211-1247(16)31325-0
WebAcetyl-coenzyme A (CoA) plays central roles in energy production, lipid metabolism, and epigenomic modifications. Here, we show that, upon genetic deletion of Acly, the gene coding for ATP-citrate lyase (ACLY), cells remain …
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Inhibition of ACLY overcomes cancer immunotherapy resistance …
https://www.science.org/doi/10.1126/sciadv.adi2465
WebDec 6, 2023 · Adenosine 5′-triphosphate citrate lyase (ACLY) is a cytosolic enzyme that converts citrate into acetyl–coenzyme A for fatty acid and cholesterol biosynthesis. ACLY is up-regulated or activated in many cancers, and targeting ACLY by inhibitors holds promise as potential cancer therapy.
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ATP citrate lyase (ACLY): a promising target for cancer ... - PubMed
https://pubmed.ncbi.nlm.nih.gov/25537655/
WebATP citrate lyase (ACLY), an important enzyme involved in lipid biogenesis linked with glucose metabolism, catalyzes the conversion of citrate to oxaloacetic acid (OAA) and acetyl-CoA.
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An allosteric mechanism for potent inhibition of human ATP ... - Nature
https://www.nature.com/articles/s41586-019-1094-6
WebApr 3, 2019 · ATP-citrate lyase (ACLY) is a central metabolic enzyme and catalyses the ATP-dependent conversion of citrate and coenzyme A (CoA) to oxaloacetate and acetyl-CoA1–5.
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47 - Gene ResultACLY ATP citrate lyase [ (human)] - National …
https://www.ncbi.nlm.nih.gov/gene/47
WebFeb 4, 2024 · ACLY as a modulator of liver cell functions and its role in Metabolic Dysfunction-Associated Steatohepatitis. ACLY-induced reprogramming of glycolytic metabolism plays an important role in the progression of breast cancer.
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Targeted inhibition of ACLY expression to reverse the resistance …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824901/
WebJan 4, 2022 · We investigated: (i) the correlation between adenosine triphosphate citrate lyase (ACLY) expression and sorafenib resistance in HCC; and (ii) if targeted inhibition could reverse sorafenib resistance. Samples of HCC tissue were obtained from patients and ACLY expression was measured.
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Acetyl-CoA metabolism in cancer | Nature Reviews Cancer
https://www.nature.com/articles/s41568-022-00543-5
WebJan 19, 2023 · Abstract. Few metabolites can claim a more central and versatile role in cell metabolism than acetyl coenzyme A (acetyl-CoA). Acetyl-CoA is produced during nutrient catabolism to fuel the...
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ACLY and CKD: A Mendelian Randomization Analysis - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263230/
WebApr 22, 2022 · Adenosine triphosphate-citrate lyase (ACLY) inhibition is a therapeutic strategy under investigation for atherosclerotic cardiovascular disease, nonalcoholic steatohepatitis, and metabolic syndrome. Mouse models suggest that ACLY inhibition could reduce inflammation and kidney fibrosis.
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Astrocyte cells in the brain have immune memory - Nature
https://www.nature.com/articles/d41586-024-00676-7
WebMar 20, 2024 · To test whether the EAE-associated increase in astrocyte pro-inflammatory responses might occur through histone modification mediated by p300, the authors engineered the deletion of Ep300 or Acly ...
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Home [www.atly.com]
https://www.atly.com/
WebKnow where to go. Find the best places to go, for whatever you’re into, anywhere in the world. Get the app. 3,661 downloads today. As seen on. Skip the hunt. Find the best restaurants, date spots, hiking trails and more through groups of …
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