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Aflibercept: Uses, Interactions, Mechani…
https://go.drugbank.com/drugs/DB08885
Mechanism of Action. Aflibercept is a 115 kDa fusion protein. It consists of an IgG backbone fused to extracellular VEGF receptor sequences of the human VEGFR1 and VEGFR2. As a soluble decoy receptor, it binds VEGF-A with a greater affinity than its natural receptors.
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Aflibercept - StatPearls - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK582136/
Web ResultJul 5, 2022 · Mechanism of Action. Aflibercept is a dimeric glycoprotein (molecular weight= 115 kDa) that acts as a … Published: 2023/07/04
Published: 2023/07/04
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Aflibercept: Uses, Interactions, Mechanism of Action | DrugBank …
https://go.drugbank.com/drugs/DB08885
Web ResultMechanism of action. Ablibercept is a recombinant fusion protein that acts as a decoy receptor for the ligands, vascular endothelial growth factor-A (VEGF …
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Aflibercept - Wikipedia
https://en.wikipedia.org/wiki/Aflibercept
OverviewMechanism of actionMedical usesContraindicationsAdverse effectsInteractionsCompositionHistoryIn wet macular degeneration, abnormal blood vessels grow in the choriocapillaris, a layer of capillaries in the eye, leading to blood and protein leakage below the macula. Aflibercept (Zaltrap) binds to circulating VEGFs and acts like a "VEGF trap". It thereby inhibits the activity of the vascular endothelial growth factor subtypes VEGF-A and VEGF-B, as well as to placental growth factor (PGF), inhibiting the growth of new blood vessels in the choriocapillaris o… Formula: C₄₃₁₈H₆₇₈₈N₁₁₆₄O₁₃₀₄S₃₂ Trade names: Eylea, Zaltrap Pregnancy category: AU: D, Not recommended
Formula: C₄₃₁₈H₆₇₈₈N₁₁₆₄O₁₃₀₄S₃₂
Trade names: Eylea, Zaltrap
Pregnancy category: AU: D, Not recommended
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Aflibercept - EyeWiki
https://eyewiki.aao.org/Aflibercept
Web ResultMechanism of Action. Aflibercept is a 115 kDa fusion protein. It consists of an IgG backbone fused to extracellular VEGF receptor sequences of the human VEGFR1 and VEGFR2. As a soluble …
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Aflibercept—a Decoy VEGF Receptor - PMC - National Center for
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5145308/
Web ResultAbstract. Aflibercept (known as ziv-aflibercept in the USA and sold under the trade name Zaltrap®) is a human recombinant fusion protein with antiangiogenic effects … Author: Kristen K. Ciombor, Jordan Berlin Publish Year: 2014
Author: Kristen K. Ciombor, Jordan Berlin
Publish Year: 2014
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Aflibercept: a Potent Vascular Endothelial Growth Factor …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873045/
Web ResultMay 29, 2012 · Aflibercept Ranibizumab Bevacizumab Pegaptanib; Molecular structure: Fusion protein: domains of VEGFR1 and VEGFR2 fused with IgG1 Fc : …
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Aflibercept - PubMed
https://pubmed.ncbi.nlm.nih.gov/35881741/
Web ResultJul 4, 2023 · Mechanism of Action. Administration. Adverse Effects. Contraindications. Monitoring. Toxicity. Enhancing Healthcare Team Outcomes. …
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Aflibercept—a Decoy VEGF Receptor | Current Oncology …
https://link.springer.com/article/10.1007/s11912-013-0368-7
Web ResultJan 21, 2014 · Aflibercept (known as ziv-aflibercept in the USA and sold under the trade name Zaltrap®) is a human recombinant fusion protein with antiangiogenic …
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Aflibercept--a decoy VEGF receptor - PubMed
https://pubmed.ncbi.nlm.nih.gov/24445500/
Web ResultAflibercept (known as ziv-aflibercept in the USA and sold under the trade name Zaltrap®) is a human recombinant fusion protein with antiangiogenic effects that …
DA: 94 PA: 58 MOZ Rank: 68
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Aflibercept in wet AMD: specific role and optimal use
https://www.tandfonline.com/doi/full/10.2147/DDDT.S40215
Web ResultAug 5, 2013 · Structure and mechanism of action. The FDA approved VEGF Trap-eye (EYLEA®, Regeneron Pharmaceutical Inc, and Bayer) for the treatment of …
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