Delta, Southwest Airlines and Frontier Airlines are the most frequent fliers to Gainesville. The majority of flights come in from Fairlie-Poplar Historic District, with Delta offering the most services on this route. How many nonstop flights are there to Gainesville?How far is Gainesville FL from Lake City Florida?
There are 41.68 miles from Gainesville to Lake City in northwest direction and 46 miles (74.03 kilometers) by car, following the I-75 N route. Gainesville and Lake City are 49 minutes far apart, if you drive non-stop. This is the fastest route from Gainesville, FL to Lake City, FL.