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Pancreatic stellate cell - Wikipedia
https://en.wikipedia.org/wiki/Pancreatic_stellate_cell
WEBPancreatic stellate cells (PaSCs) are classified as myofibroblast-like cells that are located in exocrine regions of the pancreas. PaSCs are mediated by paracrine and autocrine stimuli and share similarities with the hepatic stellate cell.
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Pancreatic stellate cells support tumour metabolism through
https://www.nature.com/articles/nature19084
WEBAug 10, 2016 · Pancreatic stellate cells (PSCs) are a predominant cell type in the pancreatic tumour stroma and are important mediators of the desmoplastic response.
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Pancreatic Stellate Cells - Rising Stars in Pancreatic Pathologies
https://ncbi.nlm.nih.gov/pmc/articles/PMC9054180/
WEBDec 30, 2021 · Pancreatic stellate cells comprise about 5 % of normal pancreas but they form about 50 % of desmoplastic stroma of PDAC, which comprise about 90 % of tumor mass (Farran et al. 2019). PDAC is characteristic by massive desmoplastic reaction, where multiple cells, including stellate cells, are involved.
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Pancreatic Stellate Cells and Metabolic Alteration: Physiology and
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967348/
WEBMar 15, 2022 · Pancreatic stellate cells play a pivotal role in the development of pancreatic fibrosis. A wide variety of external stimuli can cause PSC activation accompanied by metabolic changes, which alters the tissue microenvironment by producing extracellular matrix proteins, cytokines, growth factors, and other mediators.
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Pancreatic stellate cells and fibrosis - Pancreatic Cancer and …
https://www.ncbi.nlm.nih.gov/books/NBK98937/
WEBIt is now known that pancreatic stellate cells (PSCs) are the principal source of fibrosis in the stroma and interact closely with cancer cells to create a tumor facilitatory environment that stimulates local tumor growth and distant metastasis.
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Pancreatic stellate cells: small cells with a big role in tissue
https://www.nature.com/articles/labinvest2012161
WEBDec 27, 2012 · PaSCs are present in low abundance in the healthy adult pancreas where they are considered ‘quiescent’ but expand into ‘activated’ cells that are perhaps the most abundant cell type of the...
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1,25(OH)2D3 inhibits pancreatic stellate cells activation and …
https://link.springer.com/article/10.1007/s12020-024-03833-0
WEB1 day ago · Pancreatic stellate cells (PSCs) are star-shaped vitamin A storage cells originally discovered in the pancreas by Wateri et al., with properties similar to hepatic stellate cells (HSCs) . Under normal physiological conditions, quiescent PSCs (qPSCs) are characterized by vitamin A–containing fat droplets and low-level expression of ECM ...
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Targeting Pancreatic Stellate Cells in Cancer - Cell Press
https://www.cell.com/trends/cancer/fulltext/S2405-8033(19)30002-0
WEBPancreatic stellate cells (PSCs) are the major contributor to the aggressive, metastatic, and resilient nature of pancreatic ductal adenocarcinoma (PDAC), which has a poor prognosis with a 5-year survival rate of 8%.
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Activation of pancreatic stellate cells attenuates ... - Nature
https://www.nature.com/articles/s41419-022-05186-w
WEBAug 31, 2021 · Activation of pancreatic stellate cells attenuates intracellular Ca 2+ signals due to downregulation of TRPA1 and protects against cell death induced by alcohol metabolites. Agnieszka A....
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Pancreatic stellate cells: what's new? - PubMed
https://pubmed.ncbi.nlm.nih.gov/28590306/
WEBRecent findings: The major themes of the recent PSC literature include: PSC interactions with the extracellular matrix and other stromal components; intracellular calcium physiology as drivers of mechanical interactions and necrosis; the relationship between proinflammatory, protumoural, angiogenic, and metabolic pathways in pancreatic …
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