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A genetic map of the response to DNA damage in human cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384976/
WEBJul 7, 2020 · These alterations, known collectively as DNA damage, have the potential to cause loss of genetic information, block transcription, halt DNA replication, impair chromosome segregation, generate mutations or produce chromosome rearrangements ( Ciccia and Elledge, 2010; Jackson and Bartek, 2009; Lindahl and Barnes, 2000 ).
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Mechanisms of damage tolerance and repair during DNA replication
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034635/
WEBApr 4, 2021 · This is where multiple DNA repair pathways are engaged based on the type of damage. Some of the common types of lesions encountered by replication forks are ribonucleotides, base lesions, cyclobutene pyrimidine dimers (CPDs), interstrand crosslinks (ICLs), DNA–protein crosslinks (DPCs), and R-loops.
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A New Map Reveals the Complicated World in Which Cells Seek to …
https://today.ucsd.edu/story/a-new-map-reveals-the-complicated-world-in-which-cells-seek-to-repair-damaged-dna
WEBMay 22, 2023 · A New Map Reveals the Complicated World in Which Cells Seek to Repair Damaged DNA. An artistic rendering of the concept of DNA damage and repair. Numerous diseases are linked to or caused by alterations that affect genomic integrity and the ability of cells to function and divide normally.
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DNA Damage Atlas: an atlas of DNA damage and repair - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10767978/
WEBJan 1, 2024 · Here, we present DNA Damage Atlas (DDA, http://www.bioinformaticspa.com/DDA/ ), the first large-scale repository of DNA damage and repair information. Currently, DDA comprises 6,030 samples from 262 datasets by 59 technologies, covering 16 species, 10 types of damage and 135 treatments.
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The impact of replication stress on replication dynamics and DNA damage …
https://www.nature.com/articles/nrg.2017.46
WEBJul 17, 2017 · The impact of replication stress on replication dynamics and DNA damage in vertebrate cells. Hervé Técher, Stéphane Koundrioukoff, Alain Nicolas & Michelle Debatisse. Nature Reviews...
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Genome-wide mapping of genomic DNA damage: methods and …
https://link.springer.com/article/10.1007/s00018-021-03923-6
WEBAug 31, 2021 · The technique of “mapping DNA adductomics” describes the molecular approaches that map a variety of forms of DNA damage, to specific locations across the nuclear and mitochondrial genomes.
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Replication stress and cancer | Nature Reviews Cancer
https://www.nature.com/articles/nrc3916
WEBApr 24, 2015 · Failures in the cellular response to replication stress, such as those caused by dysfunctions of the DNA-damage checkpoint, replication fork restart or DNA repair, are tumorigenic, as...
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Mechanistic insights into DNA damage recognition and ... - Nature
https://www.nature.com/articles/s41477-024-01652-9
WEBMar 19, 2024 · In step 1, recognition of the damaged DNA depends on the type of DNA lesions: replication stress or SSBs are recognized by the RAD9–RAD1–HUS1 (9-1-1) complex or by replication protein A...
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A new map reveals the complicated world in which cells seek to …
https://phys.org/news/2023-05-reveals-complicated-world-cells-dna.html
WEBMay 22, 2023 · A new map reveals the complicated world in which cells seek to repair damaged DNA. by University of California - San Diego. An artistic rendering of the concept of DNA damage and repair....
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24.2: DNA Mutations, Damage, and Repair - Biology LibreTexts
https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/03%3A_Unit_III-_Information_Pathway/24%3A_DNA_Metabolism/24.02%3A_DNA_Mutations_Damage_and_Repair
WEBDNA mutations can also result through the replication of DNA that has been damaged by endogenous or exogenous agents.
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