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Replication Fork Stalling and the Fork Protection Complex
https://www.nature.com/scitable/topicpage/replication-fork-stalling-and-the-fork-protection-14435782/
WEBWhat Happens at the Replication Fork? Two main activities happen at the fork: DNA unwinding and DNA synthesis. The RF unwinds the unreplicated DNA ahead of it through a helicase enzyme complex...
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Replication Fork | Science Primer
https://scienceprimer.com/replication-fork
WEBThe replication fork is a region where a cell's DNA double helix has been unwound and separated to create an area where DNA polymerases and the other enzymes involved can use each strand as a template to synthesize a new double helix. An enzyme called a helicase catalyzes strand separation.
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The Replication Fork: Understanding the Eukaryotic Replication
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627427/
WEBJan 29, 2013 · Replication processes permit the copying of a single DNA double helix into two DNA helices, which are divided into the daughter cells at mitosis. The major enzymatic functions carried out at the replication fork are well conserved from prokaryotes to …
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9.2: DNA Replication - Biology LibreTexts
https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Concepts_in_Biology_(OpenStax)/09%3A_Molecular_Biology/9.02%3A_DNA_Replication
WEBMar 17, 2022 · Two replication forks are formed at the origin of replication, and these get extended in both directions as replication proceeds. There are multiple origins of replication on the eukaryotic chromosome, such that replication can occur simultaneously from several places in the genome.
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Molecular mechanism of DNA replication - Khan Academy
https://www.khanacademy.org/science/ap-biology/gene-expression-and-regulation/replication/a/molecular-mechanism-of-dna-replication
WEBSpecialized proteins recognize the origin, bind to this site, and open up the DNA. As the DNA opens, two Y-shaped structures called replication forks are formed, together making up what's called a replication bubble. The replication forks will move in opposite directions as replication proceeds.
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DNA structure and replication review (article) | Khan Academy
https://www.khanacademy.org/science/ap-biology/gene-expression-and-regulation/replication/a/hs-dna-structure-and-replication-review
WEBThe replication fork is the branched (forked) DNA at either end of the replication bubble. The replication complex is the group of proteins that help synthesize the new DNA strands. A replication unit is any chunk of DNA that is capable of being replicated — e.g. a plasmid with an origin of replication (ORI) is a replication unit.
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Making Choices: DNA Replication Fork Recovery Mechanisms
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098667/
WEBDNA replication is laden with obstacles that slow, stall, collapse, and break DNA replication forks. At each obstacle, there is a decision to be made whether to bypass the lesion, repair or restart the damaged fork, or to protect stalled forks from further demise.
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Eukaryotic DNA Replication Fork - PMC - National Center for
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597965/
WEBJun 6, 2017 · 1. INTRODUCTION. Cellular DNA replication mechanisms are highly conserved. All organisms in the three kingdoms of life carry out semiconservative DNA replication, as originally hypothesized by Watson and Crick ( 1 ). All organisms also have solved the mode of replication of antiparallel double-stranded DNA (dsDNA) in …
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Replication fork reversal in eukaryotes: from dead end to dynamic
https://www.nature.com/articles/nrm3935
WEBFeb 25, 2015 · Replication fork reversal is a complex transaction that requires the coordinated unwinding and annealing of parental and newly synthesized strands at the replication fork. Replication fork...
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The plasticity of DNA replication forks in response to clinically
https://www.nature.com/articles/s41580-020-0257-5
WEBJul 1, 2020 · Replication fork plasticity. Although the bulk of genome replication is carried out by well-characterized mechanisms that involve standard three-way junction replication forks, growing...
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