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Neoantigen T-Cell Receptor Gene Therapy in Pancreatic Cancer
https://www.nejm.org/doi/full/10.1056/NEJMoa2119662
WEBJun 9, 2022 · Adoptive Immunotherapy with T-Cell Receptor (TCR)–Engineered T Cells Targeting KRAS G12D in a Patient with Pancreatic Cancer. On day 0, the patient received a single infusion of 16.2×10...
DA: 92 PA: 35 MOZ Rank: 77
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Killing Pancreatic Cancer with T Cells that …
https://www.ucsf.edu/news/2022/12/424466/killing-pancreatic-cancer-t-cells-supercharge-themselves
WEBDec 15, 2022 · Scientists at UC San Francisco have engineered T-cells to produce a potent anti-cancer cytokine, but only when they encounter tumor cells. The immunotherapy eliminated melanoma and pancreatic …
DA: 29 PA: 65 MOZ Rank: 27
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CAR T-cell Therapy for Pancreatic Cancer - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491361/
WEBAbstract. Chimeric antigen receptor (CAR) T-cell therapy utilizes genetic engineering to redirect a patient’s own T cells to target cancer cells. The remarkable results in … Author: Carl J. DeSelm, Zachary E. Tano, Anna M. Varghese, Prasad S. Adusumilli DOI: 10.1002/jso.24627 Publish Year: 2017 Published: 2017/07
Author: Carl J. DeSelm, Zachary E. Tano, Anna M. Varghese, Prasad S. Adusumilli
DOI: 10.1002/jso.24627
Publish Year: 2017
Published: 2017/07
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The Potential of CAR T Cell Therapy in Pancreatic Cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167429/
WEBSep 25, 2018 · As such, chimeric antigen receptor (CAR) T cell therapy represents an emerging therapeutic option for pancreatic cancer. This modality utilizes genetically … Author: Mehmet Akce, Mohammad Y. Zaidi, Edmund K. Waller, Bassel F. El-Rayes, Gregory B. Lesinski DOI: 10.3389/fimmu.2018.02166 Publish Year: 2018 Publication: Front Immunol. 2018; 9: 2166.
Author: Mehmet Akce, Mohammad Y. Zaidi, Edmund K. Waller, Bassel F. El-Rayes, Gregory B. Lesinski
DOI: 10.3389/fimmu.2018.02166
Publish Year: 2018
Publication: Front Immunol. 2018; 9: 2166.
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The next wave of cellular immunotherapies in pancreatic cancer
https://www.cell.com/molecular-therapy-family/oncology/fulltext/S2372-7705(22)00014-6
WEBadoptive T cell therapy. CAR T cell therapy. tumor microenvironment. checkpoint blockade. combination therapy. preclinical models. organoids. Introduction. Pancreatic …
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Arming T cells to infiltrate pancreatic tumours - Nature
https://www.nature.com/articles/s41551-021-00821-x
WEBNov 12, 2021 · The efficacy of adoptive cell therapy for pancreatic cancer can be augmented by antigen-specific cytotoxic T cells genetically engineered to overexpress a …
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The next wave of cellular immunotherapies in pancreatic cancer
https://www.sciencedirect.com/science/article/pii/S2372770522000146
WEBMar 17, 2022 · Cellular immunotherapy, such as chimeric antigen receptor (CAR) T cell therapy, has had significant success in treating hematological malignancies. However, …
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Neoantigen T-Cell Receptor Gene Therapy in Pancreatic …
https://www.nejm.org/doi/pdf/10.1056/NEJMoa2119662?articleTools=true
WEBThe resistance of pancreatic cancer to immunotherapy could be due in part to a paucity of neoantigen-reactive tumor-infiltrating lymphocytes resulting from the low mutational …
DA: 27 PA: 39 MOZ Rank: 3
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T cells in pancreatic cancer stroma - PMC - National Center for
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8678814/
WEBDec 12, 2021 · KRAS -mutated pancreatic cells regulate the maintenance of immunoregulatory microenvironment by inducing the release of interleukin (IL)-6, IL-10 …
DA: 75 PA: 90 MOZ Rank: 53
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T cells armed with C-X-C chemokine receptor type 6 enhance
https://www.nature.com/articles/s41551-021-00737-6
WEBArticle. Published: 03 June 2021. T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours. Stefanie Lesch. Viktoria …
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