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Anti-VGKC-complex encephalitis - Wikipedia
https://en.wikipedia.org/wiki/Anti-VGKC-complex_encephalitis
WEBAnti-VGKC-complex encephalitis are caused by antibodies against the voltage gated potassium channel -complex (VGKC-complex) and are implicated in several autoimmune conditions including limbic encephalitis, epilepsy and neuromyotonia (i.e. Isaacs' Syndrome). [1] Research into autoimmune encephalitides have significantly advanced …
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Voltage-gated potassium channel - Wikipedia
https://en.wikipedia.org/wiki/Voltage-gated_potassium_channel
WEBVoltage-gated potassium channels ( VGKCs) are transmembrane channels specific for potassium and sensitive to voltage changes in the cell's membrane potential. During action potentials, they play a crucial role in returning the depolarized cell to a resting state. Classification. Alpha subunits form the actual conductance pore.
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Voltage gated potassium channel (VGKC) antibody encephalitis
https://radiopaedia.org/articles/voltage-gated-potassium-channel-vgkc-antibody-encephalitis
WEBNov 18, 2021 · Voltage-gated potassium channel (VGKC) antibody encephalitis describes a small group of autoimmune encephalitides with antibodies against components of the voltage-gated potassium channel. It is one of the most common forms of autoimmune limbic encephalitis in the absence of primary extra-CNS tumors.
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Clinical relevance of positive voltage-gated potassium channel (VGKC
https://jnnp.bmj.com/content/85/6/625
WEBBackground Voltage-gated potassium channel (VGKC)-complex antibodies can be associated with a range of immunotherapy-responsive clinical presentations including limbic encephalitis, Morvan's syndrome and acquired neuromyotonia. However, there are patients with positive levels in whom the significance is uncertain.
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Clinical utility of seropositive voltage-gated potassium channel
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100709/
WEBNov 13, 2015 · Antibodies against voltage-gated potassium channel (VGKC)–complex are implicated in the pathogenesis of acquired neuromyotonia, limbic encephalitis, faciobrachial dystonic seizure, and Morvan syndrome. Outside these entities, the clinical value of VGKC-complex antibodies remains unclear. Methods:
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Voltage-gated potassium channel-complex autoimmunity and
https://pubmed.ncbi.nlm.nih.gov/27112678/
WEBVoltage-gated potassium channel (VGKC)-complex antibodies are defined by the radioimmunoprecipitation of Kv1 potassium channel subunits from brain tissue extracts and were initially discovered in patients with peripheral nerve hyperexcitability (PNH).
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Voltage-gated potassium channel antibodies | Neurology
https://www.neurology.org/doi/10.1212/wnl.0000000000002644
WEBApr 1, 2016 · A radioimmunoassay (RIA) to detect antibodies against what was initially believed to be voltage-gated potassium channels (VGKC) in patients with neuromyotonia was established 20 years ago. 1 The rationale for this test came from previous RIA assays that detected antibodies against acetylcholine receptors or voltage-gated calcium …
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When should we test for voltage-gated potassium channel …
https://pubmed.ncbi.nlm.nih.gov/27469409/
WEBAbstract. Patients with voltage-gated potassium channel (VGKC)-complex antibodies are increasingly recognized as having central, peripheral or combined phenotypes. With increasing awareness, more patients are tested and the clinical spectrum is expanding. Consequently, clinicians may be uncertain as to which patients should or should not be …
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VGKC-Complex Antibody Encephalitis: Clinical Manifestations …
https://www.neurology.org/doi/10.1212/WNL.86.16_supplement.P2.251
WEBApr 5, 2016 · Background: VGKC encephalitis is a recently recognized autoimmune condition with antibodies against components of the VGKC protein complex. Clinical presentation can vary, but patients typically present with limbic encephalitis involving cognitive impairment, seizures and psychiatric symptoms.
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VGKC positive autoimmune encephalopathy mimicking dementia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229339/
WEBDec 1, 2011 · Voltage gated potassium channel antibodies (VGKC Abs) are known to cause three rare neurological syndromes- neuromyotonia, Morvan’s syndrome and limbic encephalitis although an increasing array of other associated neurological symptoms are becoming recognised.
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