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c-FLIP, a master anti-apoptotic regulator - PubMed
https://pubmed.ncbi.nlm.nih.gov/23070002/
WebCellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein (c-FLIP) is a master anti-apoptotic regulator and resistance factor that suppresses tumor necrosis factor-α (TNF-α), Fas-L, and TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis, as well as apoptosis triggered by chemotherapy agents in malignant cells. c-FLIP is ...
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Roles of c-FLIP in Apoptosis, Necroptosis, and Autophagy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219646/
WebCellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein (c-FLIP) is a major antiapoptotic protein and an important cytokine and chemotherapy resistance factor that suppresses cytokine- and chemotherapy-induced apoptosis. c-FLIP is expressed as long (c-FLIPL), short (c-FLIPS), and c-FLIPR splice variants in human cells. c-FLIP binds...
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Cellular FLICE-like inhibitory protein (cFLIP) critically maintains
https://www.nature.com/articles/s41419-021-03683-y
WebApr 9, 2021 · Cellular FLICE-like inhibitory protein (cFLIP) critically maintains apoptotic resistance in human lens epithelial cells | Cell Death & Disease. Article. Open access....
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c-FLIP, A MASTER ANTI-APOPTOTIC REGULATOR - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817998/
WebCellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein (c-FLIP) is a master anti-apoptotic regulator and resistance factor that suppresses tumor necrosis factor-α (TNF-α), Fas-L, and TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis, as well as apoptosis triggered by chemotherapy agents in malignant cells. c-FLIP is ...
DA: 1 PA: 1 MOZ Rank: 88
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cFLIP suppression and DR5 activation sensitize senescent ... - Nature
https://www.nature.com/articles/s43018-022-00462-2
WebNov 22, 2022 · Nature Cancer - Bernards and colleagues identify cFLIP as a common dependency of cancer cells by conferring protection from senolytic-induced cell death. They nominate combination of DR5...
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cFLIP
https://www.cell.com/cell-reports/fulltext/S2211-1247(23)01488-2
WebNov 20, 2023 · Here, we explore the role of cFLIP in regulating inflammatory outcomes of Fas and TRAIL receptor engagement and show that cFLIP L acts as a potent suppressor of inflammation, as well as cell death, which runs counter to the paradigm that suppressors of cell death typically enhance inflammation.
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cFLIP regulation of lymphocyte activation and development
https://www.nature.com/articles/nri1787
WebMar 1, 2006 · Cellular caspase-8 (FLICE)-like inhibitory protein (cFLIP) is an enzymatically inert homologue of caspase-8 that competes with caspase-8 for recruitment to the death-inducing...
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FLIP the Switch: Regulation of Apoptosis and Necroptosis by cFLIP
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691174/
WebDec 18, 2015 · In this review, we will focus on three topics of the physiological roles of cFLIP as follows: (1) molecular functions of cFLIP in death receptor-mediated apoptosis pathway, ripoptosome formation, and necroptosis; (2) quantitative regulation of cFLIP by the ubiquitin-proteasome system; and (3) physiological roles of cFLIP to maintain tissue and ...
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cFLIP – An interacting partner and a novel substrate for pro …
https://www.sciencedirect.com/science/article/pii/S2405580824000463
Webopen access. Highlights. •. Reported HtrA2-cFLIP interaction, where latter is associated with several diseases. •. Purified and biophysically characterized full-length cFLIP. •. Confirmed domain-level binding and identified key interacting residues. •. For the first time, we demonstrated that cFLIP is a substrate of HtrA2. •.
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FLIP the Switch: Regulation of Apoptosis and Necroptosis by cFLIP
https://pubmed.ncbi.nlm.nih.gov/26694384/
WebDec 18, 2015 · In this review, we summarize the current scientific findings from biochemical analyses, cell biological studies, mathematical modeling, and gene-manipulated mice models to illustrate the critical role of cFLIP as a switch to determine the destiny of cells among survival, apoptosis, and necroptosis.
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