Keyword Analysis & Research: replication of viral genome
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Viral replication - Wikipedia
Viral replication is the formation of biological viruses during the infection process in the target host cells. Viruses must first get into the cell before viral replication can occur. Through the generation of abundant copies of its genome and packaging these copies, the virus continues infecting new hosts. Replication between viruses is greatly varied and depends on the type of genes ...
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Coronavirus genome structure and replication
The basic organization of the coronavirus genome is shared with other members of the Nidovirus order (the torovirus genus, also in the family Coronaviridae, and members of the family Arteriviridae) in that the nonstructural proteins involved in proteolytic processing, genome replication, and subgenomic mRNA synthesis (transcription) (an ...
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Virus - Wikipedia
Replication involves synthesis of viral messenger RNA (mRNA) from "early" genes (with exceptions for positive sense RNA viruses), viral protein synthesis, possible assembly of viral proteins, then viral genome replication mediated by early or regulatory protein expression. This may be followed, for complex viruses with larger genomes, by one or ...
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Learn How Virus Replication Occurs - ThoughtCo
The basic process of viral infection and virus replication occurs in 6 main steps. Adsorption - virus binds to the host cell. Penetration - virus injects its genome into host cell. Viral Genome Replication - viral genome replicates using the host's cellular machinery. Assembly - viral components and enzymes are produced and begin to assemble.
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Adenovirus: Structure and genome, Replication ...
Transport of viral DNA into nucleus; The viral nucleocapsid is transported from cytosol to nucleus by the help of microtubules. Step III: Early Transcription. It is the early event in viral replication, and occurs before viral DNA synthesis begins. It is the preparatory phase in which transcription of viral DNA occurs to mRNA (early transcript).
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Coronavirus: how a large RNA viral genome is replicated ...
Coronaviruses are important human and animal pathogens and contain an extraordinarily long (27-31 kb) RNA genome. Its RNA synthesis involves complex mechanisms of regulation, similar to those of DNA viruses. In this treatise, mouse hepatitis virus (MHV) is used as a model for the discussion of the mechanism of viral RNA synthesis.
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Plasmid - Wikipedia
In order for plasmids to replicate independently within a cell, they must possess a stretch of DNA that can act as an origin of replication.The self-replicating unit, in this case, the plasmid, is called a replicon.A typical bacterial replicon may consist of a number of elements, such as the gene for plasmid-specific replication initiation protein (Rep), repeating units called iterons, DnaA ...
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Emerging coronaviruses: Genome structure, replication, and ...
It is reported that N protein can bind to nsp3 protein to help tether the genome to RTC, and package the encapsidated genome into virions. 56-58 N is also an antagonist of interferon (IFN) and viral encoded repressor of RNA interference, which appears to be beneficial for the viral replication. 59. 3.1 Diversity of CoV pathogenesis
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» What is the mutation rate during genome replication?
Using an order of magnitude of 100 replications per generation, we arrive at 0.1-1 mutations per genome per replication. Though we discuss mutations on a per replication or per generation rate, non-dividing cells will also have damage caused to their genomes through mechanisms such as radiation and reactive oxygen species.
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