Keyword Analysis & Research: somatic hypermutation
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Somatic hypermutation - Wikipedia
https://en.wikipedia.org/wiki/Somatic_hypermutation
WEBSomatic hypermutation (or SHM) is a cellular mechanism by which the immune system adapts to the new foreign elements that confront it (e.g. microbes). A major component of the process of affinity maturation , SHM diversifies B cell receptors used to recognize foreign elements ( antigens ) and allows the immune system to adapt its response to ...
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Somatic Hypermutation - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/immunology-and-microbiology/somatic-hypermutation
WEBSomatic hypermutation is a process in which point mutations accumulate in the antibody V-regions of both the heavy and light chains, at rates that are about 10 6-fold higher than the background mutation rates observed in other genes (Figure 1). This accumulation of mutations at the V-region genes occurs at the centroblast stage of B-cell ...
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Mutating for Good: DNA Damage Responses During Somatic Hypermutation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423074/
WEBMar 12, 2019 · Somatic hypermutation (SHM) of immunoglobulin (Ig) genes plays a key role in antibody mediated immunity. SHM in B cells provides the molecular basis for affinity maturation of antibodies. In this way SHM is key in …
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Somatic hypermutation - Latest research and news | Nature
https://www.nature.com/subjects/somatic-hypermutation
WEBApr 20, 2024 · Somatic hypermutation is a process that allows B cells to mutate the genes that they use to produce antibodies. This enables the B cells to produce antibodies that...
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Targeting of somatic hypermutation | Nature Reviews Immunology
https://www.nature.com/articles/nri1896
WEBAug 1, 2006 · Matthew D. Shoulders. Nature Methods (2021) Somatic hypermutation (SHM) introduces mutations in the variable region of immunoglobulin genes, to generate high-affinity B-cell antigen receptors....
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Somatic hypermutation and affinity maturation: Video | Osmosis
https://www.osmosis.org/learn/Somatic_hypermutation_and_affinity_maturation
WEBSomatic hypermutation is a cellular mechanism by which the immune system adapts to the new foreign elements that confront it (e.g. microbes), whereas affinity maturation refers to the process of increasing the specificity and strength of the interaction between an antibody and its target antigen to increase the effectiveness of the immune response.
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Somatic Hypermutation - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/medicine-and-dentistry/somatic-hypermutation
WEBSomatic Hypermutation. As a given antigen-specific B cell clone progresses from the early primary response through to the tertiary response (and beyond), successive rounds of somatic hypermutation lead to the accumulation of point mutations primarily in the CDR1 and CDR2 regions of VH and VL.
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Somatic hypermutation | Nature Communications
https://www.nature.com/subjects/somatic-hypermutation/ncomms
WEBNov 24, 2023 · The process of somatic hypermutation, used by B cells to increase antibody diversity, is catalysed by the activation-induced deaminase (AID), which needs to...
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Taming AID mutator activity in somatic hypermutation
https://www.sciencedirect.com/science/article/pii/S096800042400077X
WEBApr 12, 2024 · Activation-induced cytidine deaminase (AID) initiates somatic hypermutation (SHM) by introducing base substitutions into antibody genes, a process enabling antibody affinity maturation in immune response. How a mutator is tamed to precisely and safely generate programmed DNA lesions in a physiological process remains unsettled, as its ...
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V(D)J recombination, somatic hypermutation and class switch
https://pubmed.ncbi.nlm.nih.gov/32031242/
WEBTo enhance both the ability of immunoglobulins to recognize and bind to foreign antigens and the effector capacities of the expressed antibodies, naive B cells will undergo class switching recombination (CSR) and somatic hypermutation (SHM).
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