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Tamoxifen - StatPearls - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK532905/
WEBApr 10, 2023 · Objectives: Explain the mechanism of action of tamoxifen. Identify the approved indications of tamoxifen, and cite some of the non-approved indications as well. Review the adverse event profile of tamoxifen therapy.
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Tamoxifen: Uses, Interactions, Mechanism of Action | DrugBank …
https://go.drugbank.com/drugs/DB00675
WEBDec 30, 2015 · Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations. 1,15,16 Tamoxifen is used alone or as an adjuvant in these treatments. 15,16 Tamoxifen may no longer be the preferred treatment for these types of cancers as …
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Tamoxifen - Wikipedia
https://en.wikipedia.org/wiki/Tamoxifen
WEBTamoxifen, sold under the brand name Nolvadex among others, is a selective estrogen receptor modulator used to prevent breast cancer in women and men. It is also being studied for other types of cancer. It has been used for Albright syndrome. Tamoxifen is typically taken daily by mouth for five years for breast cancer.
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The mechanism of tamoxifen in breast cancer prevention - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3300587/
WEBMay 29, 2001 · Tamoxifen (TAM) is known to have a dual mechanism of action: (1) to compete with 17β-estradiol (E 2) at the receptor site and to block the promotional role of E 2 in breast cancer; and (2) to bind DNA after metabolic …
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TAMOXIFEN - Pharmaceuticals - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK304326/
WEBFor reduction in the incidence of breast cancer in women at high risk, the recommended dosage of tamoxifen is 20 mg daily given for 5 years. For the treatment of advanced (metastatic) breast cancer in men, the usual dosage of tamoxifen is 20–40 mg daily.
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Frontiers | Progress in the Understanding of the Mechanism of Tamoxifen
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.592912/full
WEBDec 8, 2020 · Tamoxifen is a drug commonly used in the treatment of breast cancer, especially for postmenopausal patients. However, its efficacy is limited by the development of drug resistance. Downregulation of estrogen receptor alpha (ERα) is an important mechanism of tamoxifen resistance.
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Tamoxifen: Mechanism of Action - Medscape
https://decisionpoint.medscape.com/oncology/viewarticle/917158
WEBDec 6, 2019 · Tamoxifen: Mechanism of Action. Jose P. Leone, MD · Dana-Farber Cancer Institute. Disclosures. December 06, 2019. 0. This transcript has been edited for clarity. Tamoxifen in breast cancer is a...
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Aromatase Inhibitors in Breast Cancer | New England Journal of Medicine
https://www.nejm.org/doi/full/10.1056/NEJMra023246
WEBJun 12, 2003 · Tamoxifen reduces bone demineralization through its agonist effect, at least in postmenopausal women, 20,21 whereas aromatase inhibitors may enhance this process by lowering circulating estrogen...
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Tamoxifen: Dosage, Mechanism/Onset of Action, Half-Life
https://www.medicine.com/drug/tamoxifen/hcp
WEBFeb 17, 2020 · Mechanism of Action. Tamoxifen is a selective estrogen receptor modulator (SERM) that competitively binds to estrogen receptors on tumors and other tissue targets, producing a nuclear complex that decreases DNA synthesis and inhibits estrogen effects; nonsteroidal agent with potent antiestrogenic properties which compete with estrogen for ...
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The mechanism of tamoxifen in breast cancer prevention
https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr404
WEBMay 31, 2001 · Tamoxifen (TAM) is known to have a dual mechanism of action: (1) to compete with 17β-estradiol (E 2) at the receptor site and to block the promotional role of E 2 in breast cancer; and (2) to bind DNA after metabolic …
DA: 69 PA: 36 MOZ Rank: 66
